After about 5 years of Hepcludex it´s time to give a follow up on the experiences with the drug. In this episode we talk to the inventor of bulvertide, S. Urban (project leader in our TRR179) and a clinician expert (P. Lampertico from Milan).
We will refer to the following questions:
Which patients benefit from bulevirtide? What about HCC and decomp. cirrhosis?
Do we need interferon for best efficacy? Are the supply chains of interferon a problem?
What do we do with treatment failures? When is someone a treatment failure?
What else is there beyond bulevirtide?
What are the prospects for bulevirtide/entry inhibition in HBV monoinfection?
The authors are refering about the latest paper „Heim, K., Sagar, Sogukpinar, Ö. Sian Llewellyn-Lacey, David A. Price, Florian Emmerich, Anke R. M. Kraft, Markus Cornberg, Sophie Kielbassa, Percy Knolle, Dirk Wohlleber, Bertram Bengsch, Tobias Boettler, Christoph Neumann-Haefelin, Robert Thimme, Maike Hofmann. Attenuated effector T cells are linked to control of chronic HBV infection. Nat Immunol 25, 1650–1662 (2024). https://doi.org/10.1038/s41590-024-01928-4„
In todays episode we learn about one of our central and service projects, which serves all research projects with their service on experimental and computational single-cell analysis with high spatial resolution.
A Podcast of our IRTG together with PIs Ulrike Protzer, Sabrina Schreiner and Marco Binder. Enjoy listening!
In this episode we interview our guests, the two TRR graduates Oliver Grünvogel and Julija Miller together with Peter Wimmer as a successful pharmaceutical manager to get insights about career as researcher in industry.
